白介素1β/IL-1β重组兔单抗
Rrmab®兔单抗
货号：bsm-52727R
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概述
产品编号
bsm-52727R
产品类型
重组兔单抗
英文名称
IL-1 beta Recombinant Rabbit mAb
中文名称
白介素1β/IL-1β重组兔单抗
英文别名
IL-1; IL1-BETA; IL1F2; IL1beta; IL-1beta; Il-1b; IL-1F2; IL1B_HUMAN; IL1B; IL-1 beta; Catabolin; IL1B_MOUSE; IL1B_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IL 1 beta: 200-269
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1T3
理论分子量
31 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 0.05% BSA, 40% Glycerol, 0.02% Proclin300.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
生长因子和激素（ Growth Factor and Hormones）
IL-1β是一种糖蛋白，它既可诱导急性期时相关蛋白的产生，也是β细胞终末分化并分泌抗体的必需因子，在免疫调节中发挥重要做 用。
IL-1β前体在细胞内合成后被酶剪切为成熟形态后排出到细胞外,IL-1β的前体有153个氨基酸。成熟形态有116个氨基酸。
IL-1β是一种糖蛋白，它既可诱导急性期时相关蛋白的产生，也是β细胞终末分化并分泌抗体的必需因子，在免疫调节中发挥重要做 用。
IL-1β前体在细胞内合成后被酶剪切为成熟形态后排出到细胞外,IL-1β的前体有153个氨基酸。成熟形态有116个氨基酸。
背景资料
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:1000-5000 |
交叉反应
交叉反应: Human
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靶标
基因名
IL1B
蛋白名
Interleukin-1 beta
亚基
Monomer.
亚细胞定位
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
相似性
Belongs to the IL-1 family.
功能
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
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具体参考文献:bsm-52727R 被引用于5文献中
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