The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011].
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human
1:500-2000
IHC-P
Human, Mouse
1:100-500
IHC-F
Human, Mouse
1:400-800
IF
Human, Mouse
1:100-500
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
ALDH1A1
蛋白名
Retinal dehydrogenase 1
亚基
Homodimer.
亚细胞定位
Cytoplasm.
组织特异性
Expressed in the liver, lung, and testis. Apparently not expressed at detectable levels in kidney, stomach, ovary, heart, and brain.
相似性
Belongs to the aldehyde dehydrogenase family.
功能
Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid.