ABCA1 Recombinant Mouse mAb (一抗) | Bioss
货号：bsm-60239M
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常见问题
概述
产品编号
bsm-60239M
产品类型
重组小鼠单抗
英文名称
ABCA1 Recombinant Mouse mAb
中文名称
腺苷三磷酸结合盒转运体A1重组鼠单抗
英文别名
ABC-1; ABC1; CERP; HDLCQTL13; HDLDT1; HPALP1; TGD; ABCA1_HUMAN; ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1 (ABC-1 | ATP-binding cassette 1); Cholesterol efflux regulatory protein; 7.6.2.1; ABCA1_MOUSE;
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from mouse ABCA1
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein G
克隆类型
Recombinant
理论分子量
254 kDa
检测分子量
254 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Cardiovascular > Atherosclerosis > Lipoprotein metabolism
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipoprotein metabolism
Metabolism > Types of disease > Cancer
Metabolism > Types of disease > Heart disease
Neuroscience > Cell Type Marker > Glia marker > Astrocyte marker
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
ABCA1是一种调节细胞内胆固醇流出的膜蛋白，其功能障碍将导致巨噬细胞内沉积大量的胆固醇而成为泡沫细胞，继而浸润血管壁，促进动脉粥样硬化的发生、发展。
背景资料
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | 1:500-2000 |
交叉反应
交叉反应: Mouse
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暂无相关产品
靶标
基因名
ABCA1
蛋白名
phospholipid-transporting ATPase ABCA1
亚基
Interacts with MEGF10.
亚细胞定位
Membrane; Multi-pass membrane protein.
组织特异性
Widely expressed, but most abundant in macrophages.
翻译后修饰
Phosphorylation on Ser-2054 regulates phospholipid efflux.
Palmitoylation by DHHC8 is essential for membrane localization.
疾病
Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
相似性
Belongs to the ABC transporter superfamily. ABCA family.
Contains 2 ABC transporter domains.
Contains 2 ABC transporter domains.
功能
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
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