FGF21 is a growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human, Rat
1:1000-5000
IHC-P
Human, Mouse, Rat
1:200-800
IHC-F
Human, Mouse, Rat
1:200-800
IF
Human, Mouse, Rat
1:200-800
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
FGF21
蛋白名
Fibroblast growth factor 21
亚细胞定位
Secreted.
组织特异性
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.
功能
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.