GOLGA7 is a multi-pass membrane protein belonging to the Erf4 family of proteins. It is the functional ortholog of the yeast Erf4 protein. Localizing to the Golgi apparatus, GOLGA7 is a widely expressed protein but its expression is absent from colon and thymus tissues. GOLGA7 is palmitoylated on two cysteine residues, and this palmitoylation is required for its interaction with golgin 160 and its Golgi-localization. GOLGA7 also forms a complex with ZDHHC9 and, together, these proteins function as a Ras palmitoyltransferase (Ras PAT) which is required for palmitoylation of H-Ras and N-Ras proteins. The palmitoylation of Ras proteins is essential for the trafficking of Ras proteins from the Golgi to the plasma membrane, thus implicating GOLGA7 in protein transport from the Golgi to the cell surface.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
IHC-P
Mouse
Human, Rat, Sheep
1:100-500
IHC-F
Mouse
Human, Rat, Sheep
1:100-500
IF
Mouse
Human, Rat, Sheep
1:100-500
交叉反应
交叉反应: Mouse (predicted: Human, Rat, Sheep)
相关产品
暂无相关产品
靶标
基因名
GOLGA7
蛋白名
Golgin subfamily A member 7
亚基
Interacts with GOLGA3. Interacts with ZDHHC9.
亚细胞定位
Golgi apparatus membrane; Lipid-anchor
组织特异性
Expressed in all tissues except colon and thymus.
翻译后修饰
Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.
相似性
Belongs to the ERF4 family.
功能
GOLGA7 (Golgi autoantigen, golgin subfamily a, 7) is a member of the golgin family and may be involved in protein transport from the Golgi to the cell surface. GOLGA7 forms a protein complex with ZDHHC9. This ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for H-RAS and N-RAS.