高分子量神经丝蛋白抗体

bsm-52851R

重组兔单抗、mIHC精品抗体

NF-H Recombinant Rabbit mAb

高分子量神经丝蛋白抗体

CMT2CC; NFH; NF-H; NF200; mKIAA0845; NFH_HUMAN; NEFH; 200 kDa neurofilament protein; Neurofilament triplet H protein; KIAA0845; NFH_MOUSE; NFH_RAT;

Rabbit

A synthesized peptide derived from human Neurofilament heavy polypeptide: 580-680

IgG

Liquid

affinity purified by Protein A

Recombinant

4C3

118 kDa

200 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. When visualised using an electron microscope, neurofilaments appear as 10nm diameter fibres of indeterminate length that generally have fine wispy protrusions from their sides. They are particularly abundant in axons of large projection neurons. They probably function to provide structural support for neurons and their synapses and to support the large axon diameters required for rapid conduction of impulses down axons. Neurofilaments are composed of a mixture of subunits, which usually includes the three neurofilament triplet proteins neurofilament light (NFL), neurofilament medium (NFM) and neurofilament heavy (NFH). Neurofilaments may also include smaller amounts of peripherin, alpha internexin, nestin and in some cases vimentin. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable. Some studies have shown that levels of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal lobe dementia, and vascular dementia.