热休克蛋白90α重组兔单抗
Rrmab®兔单抗
货号：bsm-52353R
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概述
产品编号
bsm-52353R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Hsp90 alpha Recombinant Rabbit mAb
中文名称
热休克蛋白90α重组兔单抗
英文别名
EL52; HEL-S-65p; HSP86; HSP89A; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; Hsp103; Hsp89; Hsp90; LAP-2; LAP2; 86kDa; 89kDa; Hsp86-1; hsp4; HS90A_HUMAN; HSP90AA1; Heat shock 86 kDa (HSP 86 | HSP86); Heat shock protein family C member 1; Lipopolysaccharide-associated protein 2 (LAP-2 | LPS-associated protein 2); Renal carcinoma antigen NY-REN-38; 3.6.4.10; HS90A_MOUSE; Tumor-specific transplantation 86 kDa antigen (TSTA); HS90A_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Hsp90 alpha: 1-52
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2A1
理论分子量
85 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
热休克蛋白-90α主要在类肌细胞、间质细胞、支持细胞核及生精细胞的胞浆表达;
HSP-90 alpha与肿瘤的关系密切，在许多肿瘤细胞中HSP90α表达升高.
背景资料
Hsp90 (heat shock protein 90) is a molecular chaperone and is one of the most abundant proteins in unstressed cells. It is an ubiquitous molecular chaperone found in eubacteria and all branches of eukarya, but it is apparently absent in archaea. Whereas cytoplasmic Hsp90 is essential for viability under all conditions in eukaryotes, the bacterial homologue HtpG is dispensable under non-heat stress conditions.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:1000-5000 | |
| IHC-P | Human, Mouse, Rat | 1:200-500 | |
| IHC-F | Human, Mouse, Rat | 1:200-500 | |
| IF | Human, Mouse, Rat | 1:200-500 | |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
HSP90AA1
蛋白名
Heat shock protein HSP 90-alpha
亚基
Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems.
亚细胞定位
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
翻译后修饰
ISGylated.
S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
相似性
Belongs to the heat shock protein 90 family.
功能
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
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