This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
基因名
EEF1A1
蛋白名
Elongation factor 1-alpha 1
亚细胞定位
Cytoplasm.
组织特异性
Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle
翻译后修饰
ISGylated.
相似性
Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.
功能
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.