碱性磷酸酶重组兔单抗
Rrmab®兔单抗
货号：bsm-52252R
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概述
产品编号
bsm-52252R
产品类型
重组兔单抗
英文名称
Alkaline phosphatase, tissue-nonspecific isozyme Recombinant Rabbit mAb
中文名称
碱性磷酸酶重组兔单抗
英文别名
AP-TNAP; APTNAP; HOPS; HPPA; HPPC; HPPI; HPPO; TNALP; TNAP; TNS-ALP; TNSALP; ALP; Akp-2; Akp2; PHOA; PPBT_HUMAN; ALPL; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; 3.1.3.1; PPBT_MOUSE; Alkaline phosphatase 2; PPBT_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Alkaline phosphatase, tissue-nonspecific isozyme: 18-50
亚型
IgG
性状
Size : 25ul/50ul/100ul/200ul
Liquid
Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
Liquid
Size : 200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1G9
理论分子量
56 kDa
浓度
1mg/ml
储存液
Size : 25ul/50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
ALP广泛分布于人体肝脏、骨骼、肠、肾和胎盘等组织,孕妇、骨折愈合期、骨软化症。佝偻病、骨细胞癌、骨质疏松、肝脓肿、肝结核、肝硬变、白血病、甲状腺机能亢进时，血清碱性磷酸酶亦可升高.
背景资料
Alkaline phosphatase (ALP) removes phosphate groups from the 5' end of DNA and RNA, and from proteins, at high pH. Most mammals have 4 different isozymes: placental, placental like, intestinal and non tissue specific (found in liver, kidney and bone). Tissues with particularly high concentrations of ALP include the liver, bile ducts, placenta, and bone. Damaged or diseased tissue releases enzymes into the blood, so serum ALP measurements can be abnormal in many conditions, including bone disease and liver disease.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ALPL
蛋白名
Alkaline phosphatase, tissue-nonspecific isozyme
亚基
Homodimer.
亚细胞定位
Cell membrane; Lipid-anchor, GPI-anchor.
翻译后修饰
Glycosylated.
疾病
Defects in ALPL are a cause of hypophosphatasia (HOPS) [MIM:146300]. HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).
Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC) [MIM:241510].
Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI) [MIM:241500].
Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC) [MIM:241510].
Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI) [MIM:241500].
相似性
Belongs to the alkaline phosphatase family.
功能
This isozyme may play a role in skeletal mineralization.
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