环氧合酶2重组兔单抗

bsm-52502R

重组兔单抗、病理级抗体、mIHC精品抗体

Cyclooxygenase 2 Recombinant Rabbit mAb

环氧合酶2重组兔单抗

COX-2; COX2; GRIPGHS; PGG/HS; PGHS-2; PHS-2; hCox-2; PES-2; PHS II; Pghs2; TIS10; PGH2_HUMAN; PTGS2; Cyclooxygenase-2 (COX-2); Prostaglandin H2 synthase 2 (PGH synthase 2 | PGHS-2); Prostaglandin-endoperoxide synthase 2; 1.14.99.1; PGH2_MOUSE; Glucocorticoid-regulated inflammatory cyclooxygenase; Macrophage activation-associated marker protein P71/73; TIS10 protein; Pghs-b; PGH2_RAT;

Rabbit

A synthesized peptide derived from human COX2: 550-604/604

IgG

Liquid

affinity purified by Protein A

Recombinant

14D5

65 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成与降解（Synthesis and Degradation） COX-2 前列腺素氧化环化酶-2是前列腺素合成的关键酶之一，为诱导性酶，他参与细胞对生长因子、肿瘤促进因子和细胞因子的反应，这些因子均能诱导COX2表达，它也参与前列腺素的合成。 COX2在80-90％的人结肠腺癌中表达显著增高，而COX1表达却不变。

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]