AIF1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
Rrmab?兔单抗
货号：bsm-54132R
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概述
产品编号
bsm-54132R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
AIF1 Recombinant Rabbit mAb
中文名称
离子钙接头蛋白单克隆抗体
英文别名
AIF-1; IBA1; IRT-1; IRT1; D17H6S50E; G1; BART-1; Bart1; mrf-1; AIF1_HUMAN; AIF1; Ionized calcium-binding adapter molecule 1; Protein G1; AIF1_MOUSE; AIF1_RAT; Microglia response factor; Mrf1;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IBA1: 1-38
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9A3
理论分子量
17 kDa
检测分子量
16 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
离子钙接头蛋白主要在小胶质细胞表达.
背景资料
Allograft Inflammatory Factor-1 (AIF1)or ionized calcium-binding adaptor molecule 1 (Iba1) is expressed selectively in microglia/macrophages and is a Ca2+-binding peptide produced by activated monocytes and microglial cells. It has been suggested that AIF1 expression is associated with chronic inflammatory processes. AIF1 is expressed by activated monocytes and might participate in a variety of pathogenic processes in the mammalian brain and in chronic transplant rejection. It has been shown to be expressed early and persistently in chronically rejecting cardiac allografts but not in cardiac syngrafts and host hearts.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:1000-2000 | |
| IHC-P | Human, Mouse, Rat | 1:200-1000 | |
| IHC-F | Human, Mouse, Rat | 1:200-1000 | |
| IF | Human, Mouse, Rat | 1:200-1000 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
AIF1
蛋白名
Allograft inflammatory factor 1
亚基
Homodimer (Potential). Monomer. Interacts with LCP1.
亚细胞定位
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
组织特异性
Detected in T-lymphocytes and peripheral blood mononuclear cells.
相似性
Contains 2 EF-hand domains.
功能
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
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