人k轻链重组兔单抗

bsm-54763R

重组兔单抗、病理级抗体

Human Ig Kappa light chain Recombinant Rabbit mAb

人k轻链重组兔单抗

HCAK1; IGKCD; Km; IGKC_HUMAN; IGKC; Ig kappa chain C region; Ig kappa chain C region AG; Ig kappa chain C region CUM; Ig kappa chain C region EU; Ig kappa chain C region OU; Ig kappa chain C region ROY; Ig kappa chain C region TI; Igk-C; IGKC_MOUSE; Ig kappa chain C region MOPC 21;

Rabbit

A synthesized peptide derived from human Human Ig kappa light chain: IgA from human colostrum(Sigma#I1010)

IgG

Liquid

affinity purified by Protein A

Recombinant

9B1

11 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

该抗体特异识别人免疫球蛋白κ轻链，可用于鉴定白血病、浆细胞瘤以及某些非霍奇金氏淋巴瘤。这些肿瘤的共同特征是只限于单个轻链的表达，因此轻链Kappa和Lamda可用于良恶性淋巴病变（反应性淋巴细胞增生和淋巴瘤）的辅助性诊断。

Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers. Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83.