MMP14 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP | Bioss

bsm-52373R

重组兔单抗

MMP14 Recombinant Rabbit mAb

基质金属蛋白酶-14重组兔单抗

MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS; MT-MMP-1; sabe; MMP14_HUMAN; MMP14; Membrane-type matrix metalloproteinase 1 (MT-MMP 1 | MTMMP1); Membrane-type-1 matrix metalloproteinase (MT1-MMP | MT1MMP); 3.4.24.80; MMP14_MOUSE; Mtmmp; MMP14_RAT; Membrane-type-1 matrix metalloproteinase (MT-MMP | MT1-MMP | MT1MMP); matrix metallopeptidase 14; matrix metalloproteinase 14 (membrane-inserted); matrix metallopeptidase 14 (membrane-inserted); membrane type 1 metalloprotease; membrane type 1-matrix metalloproteinase

Rabbit

A synthesized peptide derived from human MMP14: 151-182

IgG

Liquid

affinity purified by Protein A

Recombinant

3A1

54/62 kDa

55 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14.
Matrix metalloproteinase-14 precursor is endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. [Catalytic activity] Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain. Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. Belongs to the peptidase M10A family.

MMP14

Matrix metalloproteinase-14

Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

The precursor is cleaved by a furin endopeptidase.

Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.