基质金属蛋白酶-14重组兔单抗

bsm-52373R

重组兔单抗

MMP14 Recombinant Rabbit mAb

基质金属蛋白酶-14重组兔单抗

MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS; MT-MMP-1; sabe; MMP14_HUMAN; MMP14; Membrane-type matrix metalloproteinase 1 (MT-MMP 1 | MTMMP1); Membrane-type-1 matrix metalloproteinase (MT1-MMP | MT1MMP); 3.4.24.80; MMP14_MOUSE; Mtmmp; MMP14_RAT; Membrane-type-1 matrix metalloproteinase (MT-MMP | MT1-MMP | MT1MMP);

Rabbit

A synthesized peptide derived from human MMP14: 151-182

IgG

Liquid

affinity purified by Protein A

Recombinant

3A1

54/62 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14.
Matrix metalloproteinase-14 precursor is endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. [Catalytic activity] Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain. Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. Belongs to the peptidase M10A family.