Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex and this complex is the primary ligand for the lymphotoxin-beta receptor. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is probably non-functional. Alternative splicing results in multiple transcript variants encoding different isoforms.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat, Rabbit, Cow, Dog, Horse
1:500-2000
ELISA
Human, Mouse, Rat, Rabbit, Cow, Dog, Horse
1:5000-10000
交叉反应
交叉反应: (predicted: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse)
相关产品
暂无相关产品
靶标
基因名
LTB
蛋白名
Lymphotoxin-beta
亚基
Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.
亚细胞定位
Membrane; Single-pass type II membrane protein (Potential).
组织特异性
Spleen and thymus.
相似性
Belongs to the tumor necrosis factor family.
功能
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.