ATG13 Rabbit pAb (一抗) - IHC-P,IHC-F,IF | Bioss
货号：bs-3864R
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概述
产品编号
bs-3864R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
ATG13 Rabbit pAb
中文名称
自噬相关蛋白13抗体
英文别名
KIAA0652; PARATARG8; 1110053A20Rik; D2Ertd391e; Harbi1; Harbi1l; RGD1310685; zgc:63526; ATG13_BOVIN; ATG13; ATG13_HUMAN; ATG13_MOUSE; ATG13_DANRE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human ATG13: 51-150/517
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
57 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Mouse, Rat | Human, Rabbit, Pig, Sheep, Chicken, Dog | 1:400-800 |
| IHC-F | Mouse, Rat | Human, Rabbit, Pig, Sheep, Chicken, Dog | 1:400-800 |
| IF | Mouse, Rat | Human, Rabbit, Pig, Sheep, Chicken, Dog | 1:100-500 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Rabbit, Pig, Sheep, Chicken, Dog)
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靶标
基因名
ATG13
蛋白名
Autophagy-related protein 13
亚基
Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via C-terminus). Interacts with ULK2 (via C-terminus).
亚细胞定位
Cytoplasm, cytosol.Preautophagosomal structure.
翻译后修饰
Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.
相似性
Belongs to the ATG13 metazoan family.
功能
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
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