phospho-MEK5 (Ser137) Rabbit pAb (一抗) | Bioss

bs-5432R

磷酸化抗体、农牧业/家禽抗体

phospho-MEK5 (Ser137) Rabbit pAb

磷酸化丝裂原活化蛋白激酶激酶5抗体

HsT17454; MAPKK5; MEK5; PRKMK5; MP2K5_HUMAN; MAP2K5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5 (MEK 5); 2.7.12.2; MKK5; MP2K5_MOUSE; MP2K5_RAT; mitogen-activated protein kinase kinase 5; dual specificity mitogen-activated protein kinase kinase 5; MAPK/ERK kinase 5; MAP2K5 | MEK5 (phospho-S137); p-MEK5; phospho-MEK5; p-MAP2K5; MAP2K5 | MEK5 (phospho-Ser137)

Rabbit

KLH conjugated Synthesised phosphopeptide derived from human MEK5 around the phosphorylation site of Ser137: AV(p-S)DS

IgG

Liquid

affinity purified by Protein A

Polyclonal

49 kDa

50 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MEK5 is a dual specificity protein kinase belonging to thr Ser/Thr protein kinase family, (MAP kinase kinase family). It is activated by phosphorylation on Ser/Thr by MAP kinase kinases and interacts specifically with ERK5, and not with another MAP kinase like P38. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). It is not phosphorylated by RAFA, RAFB or RAFC and it may interact with GTPases such as CDC42. The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. MEK5 is expressed in many adult tissues and is most abundant in heart and skeletal muscle.