HDAC1 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss
货号：bs-1414R
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概述
产品编号
bs-1414R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
HDAC1 Rabbit pAb
中文名称
组蛋白去乙酰化酶1抗体
英文别名
GON-10; HD1; KDAC1; RPD3; RPD3L1; Hdac1-ps; MommeD5; HDAC1_BOVIN; HDAC1; Protein deacetylase HDAC1; Protein deacylase HDAC1; 3.5.1.98; HDAC1_HUMAN; HDAC1_MOUSE; HDAC1_RAT; histone deacetylase 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human HDAC1: 381-482/482
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
53 kDa
检测分子量
53 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Heart > Hypertrophy
Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation
Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HDACs > Class I
Isotype/Loading Controls > Loading Controls > HDAC1
Stem Cells > Signaling Pathways > Wnt > HDACs
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
组蛋白去乙酰化酶(HDACs)是一组在细胞染色质水平、通过诱导组蛋白去乙酰化来调控包括染色质重组、转录活化或抑制、细胞周期、细胞分化及细胞凋亡等一系列生物学效应的酶，特别是与细胞活化后的基因转录表达调控有关。
背景资料
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat, Pig, Sheep, Cow, Dog, GuineaPig | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Pig, Sheep, Cow, Dog, GuineaPig | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Pig, Sheep, Cow, Dog, GuineaPig | 1:100-500 |
| IF | Human | Mouse, Rat, Pig, Sheep, Cow, Dog, GuineaPig | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Pig, Sheep, Cow, Dog, GuineaPig | 1:50-300 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Pig, Sheep, Cow, Dog, GuineaPig)
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靶标
基因名
HDAC1
蛋白名
Histone deacetylase 1
亚细胞定位
Nucleus.
组织特异性
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
翻译后修饰
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.
相似性
Belongs to the histone deacetylase family. HD type 1 subfamily.
功能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
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