Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
IHC-P
Human, Mouse, Rat
1:100-500
IHC-F
Human, Mouse, Rat
1:100-500
IF
Human, Mouse, Rat
1:100-500
ICC/IF
Human, Mouse, Rat
1:50 - 1:200
ELISA
Human, Mouse, Rat
1:1000-5000
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
SLC39A14
蛋白名
Metal cation symporter ZIP14
亚基
Homotrimer.
亚细胞定位
Cell membrane. Cell projection > lamellipodium. Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
组织特异性
Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.
相似性
Belongs to the ZIP transporter (TC 2.A.5) family.
功能
May be able to transport iron (By similarity). Acts as a zinc-influx transporter.