BF647标记的一氧化氮合成酶-3（内皮型）单克隆抗体

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货号：bsm-33176M-BF647
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概述

产品编号
bsm-33176M-BF647
英文名称
eNOS Mouse mAb, BF647 conjugated
中文名称
BF647标记的一氧化氮合成酶-3（内皮型）单克隆抗体
英文别名
NOS-3; cNOS; Constitutive NOS; EC NOS; ecNOS; Endothelial nitric oxidase synthase; Endothelial nitric oxide synthase; Endothelial nitric oxide synthase 3; Endothelial NOS; Nitric oxide synthase 3(endothelial cell); Nitric oxide synthase 3; Nitric oxide synthase 3 endothelial cell; Nitric oxide synthase endothelial; nitric oxide synthase, endothelial; NOS 3; NOS III; NOS type III; NOS3; NOSIII; NOS3_HUMAN.
标记
BF647
Excitation spectrum: 647nm
Emission spectrum: 666nm
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from human eNos
亚型
IgG
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
克隆号
8G1
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域

Cancer > Cancer Metabolism > Response to hypoxia

Cardiovascular > Blood > Platelets

Cardiovascular > Vasculature > Vasodilation > Nitric oxide associated

Cell Biology > Other Antibodies > Oxidative Stress

Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

Neuroscience > Neurotransmission > Nitric Oxide > NOS

SWISS
P29474
Gene ID
4846
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
数据库链接

Entrez Gene : 287024 Cow

Entrez Gene : 4846 Human

Entrez Gene : 18127 Mouse

Entrez Gene : 24600 Rat

Omim : 163729 Human

SwissProt : P29473 Cow

SwissProt : P29474 Human

SwissProt : P70313 Mouse

SwissProt : Q62600 Rat

Unigene : 647092 Human

Unigene : 258415 Mouse

Unigene : 44265 Rat

产品介绍
合成与降解（Synthesis and Degradation)
催化生物体内一氧化氮（NO）生成的酶。分神经型一氧化氮合成的酶（nNOS or NOS-1）、诱导型一氧化氮合成的酶（iNOS or NOS-2）、内皮型一氧化氮合成的酶（eNOS or NOS-3）。此抗体识别分子量为135kDa的内皮型一氧化氮合成的酶。
背景资料
Nitric oxide synthase NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti tumor and anti pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS).

产品应用

应用已检合格种属预测种属推荐稀释比例
IFMouse, Rat, Human1:100-500

交叉反应

交叉反应: Mouse, Rat (predicted: Human)

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靶标

基因名
NOS3
蛋白名
Nitric oxide synthase, endothelial
亚基
Homodimer. Interacts with NOSIP and NOSTRIN.
亚细胞定位
Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
组织特异性
Platelets, placenta, liver and kidney.
翻译后修饰
Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity. Phosphorylation of Ser-114 by CDK5 reduces activity.
相似性
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.
功能
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.

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