STXBP1/Munc18-1 Rabbit pAb (一抗) | Bioss
货号：bs-3954R
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概述
产品编号
bs-3954R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
STXBP1/Munc18-1 Rabbit pAb
中文名称
神经突触前膜胞内蛋白18抗体
英文别名
DEE4; MUNC18-1; N-Sec1; NSEC1; P67; RBSEC1; UNC18; unc-18A; unc18-1; MMS10-G; Ms10g; Munc-18a; Rb-sec1; Sxtbp1; Unc18h; ANC18HA; NSEC1A; Sec1; rbSec1A; rbSec1B; unc-18-1; STXB1_CHICK; STXBP1; Protein unc-18 homolog 1 (Unc18-1); Protein unc-18 homolog A (Unc-18A); UNC18A; STXB1_HUMAN; STXB1_MOUSE; STXB1_RAT; syntaxin binding protein 1; syntaxin-binding protein 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Munc18: 11-110/594
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
68 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy
Metabolism > Types of disease > Cancer
Neuroscience > Cell Type Marker > Neuron marker > Synapse marker
Neuroscience > Neurotransmission > Secretory Vesicles > Munc18
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Rat | Human, Mouse, Pig, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Pig, Chicken, Dog, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Pig, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Mouse, Pig, Chicken, Dog, Horse)
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靶标
基因名
STXBP1
蛋白名
Syntaxin-binding protein 1
亚基
Binds SYTL4. Interacts with STX1A.
亚细胞定位
Cytoplasm. Membrane; Peripheral membrane protein.
组织特异性
Brain and spinal cord. Highly enriched in axons.
疾病
Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
相似性
Belongs to the STXBP/unc-18/SEC1 family.
功能
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
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