BMP2 Rabbit pAb (一抗) - WB | Bioss

Cancer > Growth factors > TGF

Cardiovascular > Angiogenesis > Growth Factors > TGF

Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Bone

Signal Transduction > Growth Factors/Hormones > TGF

Stem Cells > Neural Stem Cells > Extracellular

Stem Cells > Signaling Pathways > TGF beta > Secreted

Entrez Gene : 650 Human

Entrez Gene : 12156 Mouse

Entrez Gene : 29373 Rat

Omim : 112261 Human

SwissProt : P12643 Human

SwissProt : P21274 Mouse

SwissProt : P49001 Rat

Unigene : 73853 Human

Unigene : 103205 Mouse

Unigene : 90931 Rat

神经干细胞标志物 BMP-2主要对未分化间充质细胞和骨系细胞起到募集和分化作用。在骨形成早期，BMP-2不仅可使未分化间质细胞向骨形成中心募集，并分化为骨系细胞，而且可使成纤维细胞、成肌细胞及骨髓的基细胞逆转分化为骨系细胞。其主要过程是：增加或抑制这些细胞内的某些特异性蛋白的分泌，使成纤维细胞分化为成骨细胞，成肌细胞快速分化为肥大的软骨细胞，并促进基质钙化。 对于成骨细胞，BMP-2则可使之维持其特有细胞表型，并诱导成骨细胞标志物的增高，促进细胞外基质钙化。在骨形成后期，BMP-2还作为一种破骨细胞分化因子与其它支持破骨细胞分化因子直接或间接刺激破骨细胞分化，参与骨的重建。

BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis.