CNX; IP90; P90; 1110069N15Rik; D11Ertd153e; PP90; CALX_CANLF; CANX; CALX_HUMAN; Major histocompatibility complex class I antigen-binding protein p88; CALX_MOUSE; CALX_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Calnexin
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
24G6
理论分子量
65 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:500-2000
IHC-P
Human
1:100-500
IHC-F
Human
1:100-500
IF
Human
1:100-500
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
CANX
蛋白名
Calnexin
亚基
Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins.
亚细胞定位
Endoplasmic reticulum membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
翻译后修饰
Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). br>Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.
相似性
Belongs to the calreticulin family.
功能
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.