ASGPR1 Rabbit pAb (一抗) - WB | Bioss

bs-4119R

农牧业/家禽抗体

ASGPR1 Rabbit pAb

唾液酸糖蛋白受体1抗体

ASGPR; ASGPR1; CLEC4H1; HL-1; Asgr; Asgr-1; RATRHL1; RHL1; ASGR1_HUMAN; ASGR1; ASGP-R 1; ASGPR 1; C-type lectin domain family 4 member H1; Hepatic lectin H1 (HL-1); ASGR1_MOUSE; Hepatic lectin 1 (HL-1 | mHL-1); ASGR1_RAT; Hepatic lectin 1 (HL-1 | rHL-1);

Rabbit

KLH conjugated synthetic peptide derived from human ASGPR1: 201-291/291 <Extracellular>

IgG

Liquid

affinity purified by Protein A

Polyclonal

32 kDa

47 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ASGR is a heterooligomeric receptor that is abundantly expressed on the sinusoidal surface of the hepatic plasma membrane. It is an endocytic receptor that rapidly binds and internalizes galactose-terminated glycoproteins (asialoglycoproteins or ASGP) from the circulation. The mouse ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The aa sequence of mouse ASGPR1 ECD is 89% and 79% identical to the ASGPR1 ECD of rat and human, respectively.