Wnt1 Rabbit pAb (一抗) | Bioss

bs-1739R

农牧业/家禽抗体

Wnt1 Rabbit pAb

信号通路Wnt1抗体

BMND16; INT1; OI15; Int-1; Wnt-1; sw; swaying; WNT1_HUMAN; WNT1; Proto-oncogene Int-1 homolog; WNT1_MOUSE; Proto-oncogene Int-1; Wnt family member 1; wingless-type MMTV integration site family, member 1

Rabbit

KLH conjugated synthetic peptide derived from human Wnt1: 251-350/370

IgG

Liquid

affinity purified by Protein A

Polyclonal

39 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Wnt1是Wnt家族的成员之一,对神经干细胞的增殖及分化有一定的调控作用,Wnt1a蛋白可以促进神经干细胞向神经元分化.

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.