SARS-CoV-2 (2019-nCoV) Nucleocapsid, WT & Ormicron Recognized
Rrmab?兔单抗
货号：bsm-41511R
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概述
产品编号
bsm-41511R
产品类型
重组兔单抗
英文名称
SARS-CoV-2 (2019-nCoV) Nucleocapsid, WT & Ormicron Recognized Recombinant Rabbit mAb
中文名称
SARS冠状病毒2核衣壳蛋白单克隆抗体（新冠抗原检测原料，可识别奥密克戎）
英文别名
NCAP_SARS2; N; Nucleocapsid protein (NC | Protein N);
抗体来源
Rabbit
免疫原
Recombinant SARS-CoV-2 Nucleocapsid Protein
亚型
IgG
性状
Size : 50ul
Liquid
Size : 100ug/200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
Liquid
Size : 100ug/200ug (PBS only)
Lyophilized
Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user.
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7B2
理论分子量
46 kDa
检测分子量
46-50 kDa
浓度
1mg/ml
储存液
Size : 50ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 100ug/200ug (PBS only)
0.01M PBS
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 100ug/200ug (PBS only)
0.01M PBS
SWISS
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Anti-SARS-CoV-2 Spike Protein S（IgM校准品）
特性：人源单抗(双链抗体)，亲和力高，批次质量稳定
识别位置：新冠病毒S蛋白RBD区域
产品应用：ELISA、胶体金层析、化学发光等
储存条件：-20℃保存，避免反复冻融。
特性：人源单抗(双链抗体)，亲和力高，批次质量稳定
识别位置：新冠病毒S蛋白RBD区域
产品应用：ELISA、胶体金层析、化学发光等
储存条件：-20℃保存，避免反复冻融。
背景资料
The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | SARS-CoV-2 WT, SARS-CoV-2 (D614G), SARS-CoV-2 Omicron and series of mutants | 1:500-2000 | |
| ELISA | SARS-CoV-2 WT, SARS-CoV-2 (D614G), SARS-CoV-2 Omicron and series of mutants | 1:5000-10000 |
交叉反应
交叉反应: SARS-CoV-2 WT, SARS-CoV-2 (D614G), SARS-CoV-2 Omicron and series of mutants
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靶标
基因名
S
蛋白名
Spike glycoprotein
亚基
Spike glycoprotein:
Homotrimer; each monomer consists of a S1 and a S2 subunit (PubMed:32155444, PubMed:32075877). The resulting peplomers protrude from the virus surface as spikes (By similarity).
Interacts with the accessory proteins 3a and 7a.
Spike protein S1:
Binds to human ACE2.
Homotrimer; each monomer consists of a S1 and a S2 subunit (PubMed:32155444, PubMed:32075877). The resulting peplomers protrude from the virus surface as spikes (By similarity).
Interacts with the accessory proteins 3a and 7a.
Spike protein S1:
Binds to human ACE2.
亚细胞定位
Virion membrane ; Single-pass type I membrane protein ; Host endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein ; Host cell membrane ; Single-pass type I membrane protein ;
Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.
Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.
组织特异性
The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.
Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins (PubMed:32155444). Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor (By similarity). The presence of a furin polybasic cleavage site sets SARS-CoV-2 S apart from SARS-CoV S that possesses a monobasic S1/S2 cleavage site processed upon entry of target cells (PubMed:32155444).
Highly decorated by heterogeneous N-linked glycans protruding from the trimer surface.
Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins (PubMed:32155444). Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor (By similarity). The presence of a furin polybasic cleavage site sets SARS-CoV-2 S apart from SARS-CoV S that possesses a monobasic S1/S2 cleavage site processed upon entry of target cells (PubMed:32155444).
Highly decorated by heterogeneous N-linked glycans protruding from the trimer surface.
翻译后修饰
The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.
Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins (PubMed:32155444). Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor (By similarity). The presence of a furin polybasic cleavage site sets SARS-CoV-2 S apart from SARS-CoV S that possesses a monobasic S1/S2 cleavage site processed upon entry of target cells (PubMed:32155444).
Highly decorated by heterogeneous N-linked glycans protruding from the trimer surface.
Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins (PubMed:32155444). Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor (By similarity). The presence of a furin polybasic cleavage site sets SARS-CoV-2 S apart from SARS-CoV S that possesses a monobasic S1/S2 cleavage site processed upon entry of target cells (PubMed:32155444).
Highly decorated by heterogeneous N-linked glycans protruding from the trimer surface.
功能
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
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