铁蛋白重组兔单抗

bsm-54108R

重组兔单抗、mIHC精品抗体

Ferritin Heavy Chain Recombinant Rabbit mAb

铁蛋白重组兔单抗

FTH; FTH1; FHC; FTHL6; HFE5; NBIA9; PIG15; PLIF; HFt; MFH; FRIH_FELCA; Ferritin H subunit; 1.16.3.1; FRIH_CANLF; FRIH_HUMAN; Cell proliferation-inducing gene 15 protein; FRIH_MOUSE;

Rabbit

A synthesized peptide derived from human Ferritin heavy chain: 150-183

IgG

Liquid

affinity purified by Protein A

Recombinant

5B5

20 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Mammalian ferritins consist of 24 subunits made up of two types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of FeII, whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of FeIII. The most prominent role of mamma-lian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.