酪氨酸羟化酶兔单克隆抗体
Rrmab®兔单抗
货号：bsm-52574R
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概述
产品编号
bsm-52574R
产品类型
重组兔单抗、帕金森相关抗体、mIHC精品抗体
英文名称
Tyrosine Hydroxylase Recombinant Rabbit mAb
中文名称
酪氨酸羟化酶兔单克隆抗体
英文别名
DYT14; DYT5b; TYH; The; TY3H_HUMAN; TH; Tyrosine 3-hydroxylase (TH); 1.14.16.2; TY3H_MOUSE; TY3H_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Tyrosine hydroxylase: 500-528
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8B6
理论分子量
60 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis
Cancer > Cancer Metabolism > Response to hypoxia
Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
Neuroscience > Cell Type Marker > Neuron marker > Soma marker
Neuroscience > Neurotransmitter > Biogenic Amines > Dopamine
Neuroscience > Neurotransmitter > Biogenic Amines > Noradrenaline
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
神经细胞标志物
酪氨酸羟化酶（TH）是儿茶酚胺类神经递质即多巴胺、去甲肾上腺素、肾上腺素生物合成过程所需的限速酶，它以四氢生物喋呤啶(BH4)为辅酶，催化酪氨酸的羟化而生成多巴(DOPA)。
已知在患帕金森病(Parkinson disease,PD)时，脑内多巴胺(dopamine,DA)的减少与此酶活性低下有关。因此对PD模型动物来说，若将TH基因植入脑内，便可以提高脑内DA水平而达到基因治疗目的。
酪氨酸羟化酶（TH）是儿茶酚胺类神经递质即多巴胺、去甲肾上腺素、肾上腺素生物合成过程所需的限速酶，它以四氢生物喋呤啶(BH4)为辅酶，催化酪氨酸的羟化而生成多巴(DOPA)。
已知在患帕金森病(Parkinson disease,PD)时，脑内多巴胺(dopamine,DA)的减少与此酶活性低下有关。因此对PD模型动物来说，若将TH基因植入脑内，便可以提高脑内DA水平而达到基因治疗目的。
背景资料
bs-0016P is one synthetic peptide derived from human TH.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
TH
蛋白名
Tyrosine 3-monooxygenase
亚基
Homotetramer.
亚细胞定位
Mainly expressed in the brain and adrenal glands.
组织特异性
Mainly expressed in the brain and adrenal glands.
翻译后修饰
In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation.
疾病
Defects in TH are the cause of Segawa syndrome autosomal recessive (ARSEGS) [MIM:605407]. A form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
相似性
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
功能
Plays an important role in the physiology of adrenergic neurons.
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具体参考文献:bsm-52574R 被引用于3文献中
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