ADAMTS10 Rabbit pAb (一抗) | Bioss
货号：bs-23478R
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概述
产品编号
bs-23478R
产品类型
农牧业/家禽抗体
英文名称
ADAMTS10 Rabbit pAb
中文名称
整合素样金属蛋白酶与凝血酶10型抗体
英文别名
ADAM-TS10; ADAMTS-10; WMS; WMS1; 9430006O18; Znmp; ATS10_HUMAN; ADAMTS10; ADAM-TS 10; 3.4.24.-; ATS10_MOUSE; ADAM metallopeptidase with thrombospondin type 1 motif 10; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human ADAMTS10 : 431-530/1103
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
95 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
ADAMTS10 is a member of the ADAMs family of proteinases with Thrombospondin motifs. The catalytic site of ADAMTS10 is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence, perhaps giving these enzymes some shared specificity. ADAMTS10 is closest in homology to ADAMTS6, sharing 53% overall identity. Functional mutations in ADAMTS10 have been linked to Weill Marchesani syndrome, a connective tissue disorder marked by fibrillin 1 misprocessing. ADAMTS10 has also been reported to be over expressed in breast cancer tissues and cell lines.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, Horse | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Mouse, Rabbit, Pig, Sheep, Cow, Horse)
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靶标
基因名
ADAMTS10
蛋白名
A disintegrin and metalloproteinase with thrombospondin motifs 10
亚基
Interacts with FBN1; this interaction promotes microfibrils assembly.
亚细胞定位
Secreted, extracellular space, extracellular matrix.
组织特异性
Widely expressed in adult tissues.
翻译后修饰
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
疾病
Defects in ADAMTS10 are the cause of Weill-Marchesani syndrome 1 (WMS1) [MIM:277600]. WMS1 is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.
相似性
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 PLAC domain.
Contains 5 TSP type-1 domains.
Contains 1 peptidase M12B domain.
Contains 1 PLAC domain.
Contains 5 TSP type-1 domains.
功能
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
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