TGF beta Receptor I Rabbit pAb (一抗) | Bioss
货号：bs-23446R
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常见问题
概述
产品编号
bs-23446R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
TGF beta Receptor I Rabbit pAb
中文名称
转移生长因子β受体1抗体
英文别名
AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TBR-i; TBRI; TGFR-1; tbetaR-I; ESK2; TbetaRI; TGFR1_BOVIN; TGFBR1; TGF-beta type I receptor; Transforming growth factor-beta receptor type I (TGF-beta receptor type I | TbetaR-I); 2.7.11.30; TGFR1_HUMAN; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5 (ALK-5 | ALK5); Serine/threonine-protein kinase receptor R4 (SKR4); TGFR1_MOUSE; TGFR1_RAT; transforming growth factor beta receptor 1; multiple self-healing squamous epithelioma; transforming growth factor beta receptor I; activin A receptor type II-like kinase, 53kDa
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human TGF beta Receptor I: 21-120/503 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
55 kDa
检测分子量
55-58 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Response to hypoxia
Cancer > Growth factors > TGF
Cardiovascular > Angiogenesis > Growth Factors > TGF
Metabolism > Pathways and Processes > Metabolism processes > Hypoxia
Signal Transduction > Growth Factors/Hormones > TGF
Stem Cells > Signaling Pathways > TGF beta > Surface Molecules
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
细胞膜受体（Membrane Receptors)TGF-βRⅠ
背景资料
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Rabbit, Pig, Sheep, Cow, Dog, Horse | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Dog, Horse)
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靶标
基因名
TGFBR1
蛋白名
TGF-beta receptor type-1
亚基
Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
组织特异性
Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
翻译后修饰
Phosphorylated at basal levels in the absence of ligand binding. Activated by multiple phosphorylation, mainly in the GS region.
相似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
Contains 1 GS domain.
Contains 1 protein kinase domain.
功能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
Subunit : Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor.
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