Neutrophil Elastase Rabbit pAb (一抗) | Bioss

bs-23548R

Neutrophil Elastase Rabbit pAb

中性粒细胞弹性蛋白酶ELANE抗体

ELA2; GE; HLE; HNE; NE; PMN-E; SCN1; F430011M15Rik; ELNE_HUMAN; ELANE; Bone marrow serine protease; Elastase-2; Human leukocyte elastase (HLE); Medullasin; PMN elastase; 3.4.21.37; ELNE_MOUSE; Leukocyte elastase;

Rabbit

KLH conjugated synthetic peptide derived from human Neutrophil Elastase : 51-150/267

IgG

Liquid

affinity purified by Protein A

Polyclonal

26 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].