phospho-MyoD1 (Ser200) Rabbit pAb (一抗) | Bioss
货号：bs-5499R
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概述
产品编号
bs-5499R
产品类型
磷酸化抗体、农牧业/家禽抗体
英文名称
phospho-MyoD1 (Ser200) Rabbit pAb
中文名称
磷酸化肌原调节蛋白抗体
英文别名
MYOD1 | BHLHC1/MYF3 (phospho-S200); p-BHLHC1/MYF3; phospho-BHLHC1/MYF3; p-MYOD1; MYOD1 | BHLHC1/MYF3 (phospho-Ser200); MyoD; CMYO17; CMYP17; MYF3; MYODRIF; PUM; bHLHc1; Myod-1; MUF3; MYF-3; MYOD1_CHICK; MYOD1; MYOD1 homolog; CMD1; MYOD1_BOVIN; MYOD1_HUMAN; Class C basic helix-loop-helix protein 1 (bHLHc1); Myogenic factor 3 (Myf-3); MYOD1_MOUSE; MYOD1_PIG; MYOD1_RAT; MYOD1_SHEEP;
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human MyoD1 around the phosphorylation site of Ser200: DA(p-S)SP
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
34 kDa
检测分子量
47 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Pig, Cow | 1:500-2000 |
| Flow-Cyt | Human | Mouse, Rat, Pig, Cow | 1ug/Test |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Pig, Cow)
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靶标
基因名
MYOD1
蛋白名
Myoblast determination protein 1
亚基
Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5 (By similarity).
亚细胞定位
Nucleus.
翻译后修饰
Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
Ubiquitinated on the N-terminus; which is required for proteasomal degradation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
Ubiquitinated on the N-terminus; which is required for proteasomal degradation.
相似性
Contains 1 bHLH (basic helix-loop-helix) domain.
功能
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
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