GLUR2 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss
货号：bs-1798R
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常见问题
概述
产品编号
bs-1798R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
GLUR2 Rabbit pAb
中文名称
谷氨酸受体2抗体
英文别名
GLUR2; GLURB; GluA2; GluR-K2; HBGR2; NEDLIB; gluR-2; gluR-B; GRIA2_HUMAN; GRIA2; AMPA-selective glutamate receptor 2; Glutamate receptor ionotropic, AMPA 2; GRIA2_MOUSE; GRIA2_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human GluR2 : 151-250/883 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
97 kDa
检测分子量
117 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing(CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Pig, Dog | 1:500-2000 |
| IHC-P | Mouse, Rat | Human, Pig, Dog | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Pig, Dog | 1:100-500 |
| IF | Mouse, Rat | Human, Pig, Dog | 1:100-500 |
| Flow-Cyt | Human, Rat | Mouse, Pig, Dog | 1μg /test |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Pig, Dog)
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靶标
基因名
GRIA2
蛋白名
Glutamate receptor 2
亚基
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP and GRIP2. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1. Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5.
亚细胞定位
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
翻译后修饰
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
相似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
功能
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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