低密度脂蛋白受体相关蛋白1重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28，RR26012026-01-04~2026-02-28，TR
一键复制 说明书 文献引用(1)
低密度脂蛋白受体相关蛋白1重组兔单抗
货号：bsm-60676R
产品详情
相关标记
相关产品
相关文献
常见问题

概述

产品编号
bsm-60676R
产品类型
重组兔单抗
英文名称
LRP1 Recombinant Rabbit mAb
中文名称
低密度脂蛋白受体相关蛋白1重组兔单抗
英文别名
A2MR; APOER; APR; CD91; DDH3; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5; b2b1554Clo; LRP-1; LRP1_HUMAN; LRP1; Alpha-2-macroglobulin receptor (A2MR); Apolipoprotein E receptor (APOER); LRP1_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human LRP1: 4450-4521
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
R1B9
理论分子量
85/515 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域

Cancer > Cell Death > Apoptosis > Metabolism

Cancer > Cell Death > Apoptosis > Phagocytosis

Cardiovascular > Atherosclerosis > Lipoprotein metabolism

Cardiovascular > Blood > Serum Proteins

Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism

Cell Biology > Apoptosis > Phagocytosis

Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism

Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipoprotein metabolism

Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

Metabolism > Types of disease > Cancer

Metabolism > Types of disease > Heart disease

Metabolism > Types of disease > Neurodegenerative disease

Metabolism > Types of disease > Obesity

Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease

Signal Transduction > Metabolism > Lipid metabolism

SWISS
Q07954
Gene ID
4035
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 4035 Human

Entrez Gene : 16971 Mouse

Entrez Gene : 299858 Rat

SwissProt : Q07954 Human

SwissProt : Q91ZX7 Mouse

背景资料
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗低密度脂蛋白受体相关蛋白1重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500
ICC/IFHuman, Mouse, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

相关产品

暂无相关产品

靶标

基因名
LRP1
蛋白名
Prolow-density lipoprotein receptor-related protein 1
亚基
Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Interacts with bacterial exotoxins.
亚细胞定位
Cell membrane. Membrane, coated pit and Cytoplasm. Nucleus. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
组织特异性
Most abundant in liver, brain and lung.
翻译后修饰
Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
The N-terminus is blocked.
Phosphorylated on serine and threonine residues.
Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
相似性
Belongs to the LDLR family.
Contains 22 EGF-like domains.
Contains 31 LDL-receptor class A domains.
Contains 34 LDL-receptor class B repeats.
功能
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

标记抗体

暂无标记数据

同靶标产品

暂无同靶标产品

相关文献

提示: 发表研究结果有使用 bsm-60676R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
具体参考文献:bsm-60676R 被引用于1文献中

暂无相关文献

常见问题

暂无常见问题