This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse
1:500-2000
IHC-P
Human, Mouse
1:100-500
IHC-F
Human, Mouse
1:100-500
IF
Human, Mouse
1:100-500
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
LYZ
蛋白名
Lysozyme C
亚细胞定位
Secreted.
疾病
Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.