CD62p Rabbit pAb (一抗) | Bioss
货号：bs-43529R
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概述
产品编号
bs-43529R
英文名称
CD62p Rabbit pAb
中文名称
P选择素/白细胞内皮细胞粘附分子3抗体
英文别名
CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM; PSEL; GMP-140; LYAM3_HUMAN; SELP; CD62 antigen-like family member P; Granule membrane protein 140 (GMP-140); Leukocyte-endothelial cell adhesion molecule 3 (LECAM3); Platelet activation dependent granule-external membrane protein (PADGEM); GMRP; LYAM3_MOUSE; selectin P; selectin P (granule membrane protein 140kD, antigen CD62); selectin P (granule membrane protein 140kDa, antigen CD62); P-selectin; antigen CD62; granule membrane protein 140kDa; platelet activation-dependent granule to external membrane protein
抗体来源
Rabbit
免疫原
Recombinant mouse P-Selectin protein: 42-709/768
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
88 kDa
检测分子量
76 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Angiogenesis > Endothelial Cell Markers
Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Cell adhesion molecules
Cardiovascular > Blood > Platelets
Immunology > Adaptive Immunity > Regulatory T Cells
Immunology > Cell Type Markers > CD > Platelets
Stem Cells > Hematopoietic Progenitors > Myeloid > Thrombocytic Lineage
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
P-选择素(P—selectin)是细胞黏附分子选择素家族的主要成员，又称CD62p，可以介导各种白细胞和肿瘤细胞的粘附。
CD62p又称GMP—140或PADGEM蛋白(血小板活化依赖α颗粒膜蛋白),它在血小板与单核细胞及中性粒细胞相互作用中起关键作用。
CD62p又称GMP—140或PADGEM蛋白(血小板活化依赖α颗粒膜蛋白),它在血小板与单核细胞及中性粒细胞相互作用中起关键作用。
背景资料
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Rat | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Rat)
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靶标
基因名
SELP
蛋白名
P-selectin
亚基
Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
疾病
Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
相似性
Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
功能
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
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