RIPK3 Mouse mAb (一抗) - WB | Bioss
货号：bsm-51714M
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bsm-51714M
英文名称
RIPK3 Mouse mAb
中文名称
受体结合丝氨酸苏氨酸激酶3单克隆抗体
英文别名
RIP3; RIPK3_HUMAN; RIPK3; RIP-like protein kinase 3; Receptor-interacting protein 3 (RIP-3); 2.7.11.1; RIPK3_MOUSE; Receptor-interacting protein 3 (RIP-3 | mRIP3);
抗体来源
Mouse
免疫原
Recombinant human RIPK3.
亚型
IgG1, k
性状
Liquid
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
克隆号
D11F6
理论分子量
57 kDa
检测分子量
57 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Receptors > Associated Proteins
Cancer > Cell Death > Necroptosis
Cell Biology > Apoptosis > Intracellular > Kinases
Cell Biology > Apoptosis > Receptors > Associated Proteins
Immunology > Innate Immunity > TLR Signaling
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-1000 |
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
RIPK3
蛋白名
Receptor-interacting serine/threonine-protein kinase 3
亚基
Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.
亚细胞定位
Cytoplasm. Cell membrane. Mitochondrion (Potential).
组织特异性
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
翻译后修饰
RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3.
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
相似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
同靶标产品
相关文献
提示: 发表研究结果有使用 bsm-51714M 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
具体参考文献:bsm-51714M 被引用于4文献中