GRP78 Mouse mAb (一抗) - WB | Bioss

bsm-51623M

GRP78 Mouse mAb

葡萄糖调节蛋白78单克隆抗体

BIP; GRP78; HEL-S-89n; BIP_HUMAN; HSPA5; 78 kDa glucose-regulated protein (GRP-78); Binding-immunoglobulin protein (BiP); Heat shock protein 70 family protein 5 (HSP70 family protein 5); Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; 3.6.4.10;

Mouse

Recombinant human HSPA5 between 420-654 amino acids.

IgG1, k

Liquid

affinity purified by Protein G

Monoclonal

D12H2

78 kDa

75 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葡萄糖调节蛋白78是热休克蛋白70家族的成员之一，又称：热休克蛋白70蛋白5,作为一种分子伴侣在蛋白质的折叠和转运过程及内质网应激反应中发挥重要作用.它在多种肿瘤组织中呈高表达.

The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.