Toll样受体2(CD282)抗体

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
Toll样受体2(CD282)抗体
货号:bsm-54147R
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概述

产品编号
bsm-54147R
产品类型
重组兔单抗
英文名称
TLR2 Recombinant Rabbit mAb
中文名称
Toll样受体2(CD282)抗体
英文别名
CD282; TIL4; TLR2_HUMAN; TLR2; Toll/interleukin-1 receptor-like protein 4;
抗体来源
Rabbit
免疫原
Recombinant full length protein of human TLR2
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3A27
理论分子量
84 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Toll样受体2(TLR2)通过激活天然免疫,参与特异性免疫应答的启动,Toll样受体2(TLR2)作为一种重要跨膜信号转导受体参与了内毒素诱发炎症反应的病理过程,对其调控机制的研究日益受到关注。
背景资料
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008].
Toll样受体2(CD282)抗体Toll样受体2(CD282)抗体Toll样受体2(CD282)抗体

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse1:1000-5000
Flow-CytHuman, Mouse1ug/Test

交叉反应

交叉反应: Human, Mouse

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靶标

基因名
TLR2
蛋白名
Toll-like receptor 2
亚基
Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3.
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
翻译后修饰
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
相似性
Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
功能
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

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