RSPO1 Rabbit pAb (一抗) | Bioss
货号：bs-21386R
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常见问题
概述
产品编号
bs-21386R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
RSPO1 Rabbit pAb
中文名称
分泌性蛋白RSPO1抗体
英文别名
CRISTIN3; RSPO; R-spondin; Rspondin; RGD1565558; RSPO1_HUMAN; RSPO1; Roof plate-specific spondin-1 (hRspo1); RSPO1_MOUSE; Cysteine-rich and single thrombospondin domain-containing protein 3 (Cristin-3 | mCristin-3); Roof plate-specific spondin-1; R-spondin 1; R-spondin homolog (Xenopus laevis)
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human RSPO1 : 21-120/263
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
27 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
R-spondin（Rspo）是近年来新发现的蛋白家族,包括4个成员（Rspo1～4）。Rspo蛋白家族所有成员均为分泌性蛋白,均有两个富含半胱氨酸的furin-like结构域、1个TSP1结构域和富含碱性氨基酸的C端区域。Rspos通过激活并协同Wnt/β-catenin信号通路参与对细胞增殖和分化的调控,影响骨骼、肌肉、血管等组织的发育以及肢体和性腺的形成,并在多种疾病的发生过程中起重要作用。
背景资料
RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Rat | Human, Rabbit, Pig, Dog | 1:100-500 |
| IHC-F | Rat | Human, Rabbit, Pig, Dog | 1:100-500 |
| IF | Rat | Human, Rabbit, Pig, Dog | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Rabbit, Pig, Dog)
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靶标
基因名
RSPO1
蛋白名
R-spondin-1
亚基
Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity).
亚细胞定位
Secreted.
组织特异性
Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen.
疾病
Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:610644]. This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin.
相似性
Belongs to the R-spondin family.
Contains 2 FU (furin-like) repeats.
Contains 1 TSP type-1 domain.
Contains 2 FU (furin-like) repeats.
Contains 1 TSP type-1 domain.
功能
Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
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