EphB2 Rabbit pAb (一抗) | Bioss
货号：bs-0247R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bs-0247R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
EphB2 Rabbit pAb
中文名称
酪氨酸蛋白激酶受体B2抗体
英文别名
BDPLT22; CAPB; DRT; EK5; EPHT3; ERK; Hek5; PCBC; Tyro5; Cek5; ETECK; Nuk; Prkm5; Qek5; Sek3; EPHB2_HUMAN; EPHB2; Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH tyrosine kinase 3; EPH-like kinase 5 (EK5 | hEK5); Renal carcinoma antigen NY-REN-47; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3; 2.7.10.1; EPTH3; EPHB2_MOUSE; Neural kinase; Nuk receptor tyrosine kinase; Tyrosine-protein kinase receptor SEK-3; EPH receptor B2
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human EphB2: 101-200/1055 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
114 kDa
检测分子量
120 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Angiogenesis > Ephrins > Eph Receptors
Neuroscience > Cell Type Marker > Neuron marker > Growth Cone
Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins
Neuroscience > Neurotransmission > Intracellular Signaling > Kinases
Neuroscience > Neurotransmission > Receptors / Channels > Tyrosine Kinase Receptors
Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Chicken, Dog | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Chicken, Dog | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Chicken, Dog | 1:100-500 |
| IF | Human | Mouse, Rat, Chicken, Dog | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Chicken, Dog)
相关产品
暂无相关产品
靶标
基因名
EPHB2
蛋白名
Ephrin type-B receptor 2
亚基
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
组织特异性
Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
疾病
Defects in EPHB2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.
功能
Receptor for members of the ephrin-B family. Phosphorylates ARHGEF15, leading to its ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation. Can function in aspects of retinal ganglion cell axon guidance to the optic disk even when lacking its tyrosine kinase domain. Acts as a tumor suppressor.
同靶标产品
相关文献
提示: 发表研究结果有使用 bs-0247R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
具体参考文献:bs-0247R 被引用于1文献中