CD11b Rabbit pAb (一抗) | Bioss
货号：bs-1014R
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概述
产品编号
bs-1014R
英文名称
CD11b Rabbit pAb
中文名称
整合素αM/巨噬细胞表面分子抗体
英文别名
CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; ITAM_HUMAN; ITGAM; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; ITAM_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from mouse CD11b: 77-180/1152
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
125 kDa
检测分子量
175 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Neuroscience > Cell Type Marker > Glia marker > Microglia marker
Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Alpha
Stem Cells > Hematopoietic Progenitors > Hematopoietic Stem Cells > Murine Lineage Negative
Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Lymphoid > NK Cell Lineage
Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Neutrophil Lineage
Stem Cells > Mesenchymal Stem Cells > Negative Markers
Tags & Cell Markers > Cell Type Markers > Neuroscience Markers > Glial
SWISS
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ITGAM
蛋白名
Integrin alpha-M
亚基
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.
亚细胞定位
Membrane.
组织特异性
Predominantly expressed in monocytes and granulocytes.
疾病
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
相似性
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6). Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
功能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
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