Integrin alpha 4 Rabbit pAb (一抗) - WB,ELISA | Bioss
货号：bs-0641R
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概述
产品编号
bs-0641R
产品类型
农牧业/家禽抗体
英文名称
Integrin alpha 4 Rabbit pAb
中文名称
整合素α4（CD49d）抗体
英文别名
CD49D; IA4; Itga4B; ITA4_HUMAN; ITGA4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; ITA4_MOUSE; Lymphocyte Peyer patch adhesion molecules subunit alpha (LPAM subunit alpha);
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Integrin alpha 4: 551-650/1032 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
111 kDa
检测分子量
150 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
整合素-α-4型 Integrin α4 (CD49d)整合素-α是介导细胞与细胞外基质粘附作用的主要因子。
背景资料
Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| ELISA | Human, Mouse, Rat | 1:5000-10000 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
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靶标
基因名
ITGA4
蛋白名
Integrin alpha-4
亚基
Heterodimer of an alpha and a beta subunit.
亚细胞定位
Membrane; Single pass type I membrane protein.
翻译后修饰
Phosphorylation on Ser-1027 inhibits PXN binding.
相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 7 FG-GAP repeats.
功能
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
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