Tropomodulin 3 Rabbit pAb (一抗) | Bioss

bs-17156R

宠物抗体、农牧业/家禽抗体

Tropomodulin 3 Rabbit pAb

原肌球蛋白调节蛋白3抗体

UTMOD; U-Tmod; TMOD3_HUMAN; TMOD3; Ubiquitous tropomodulin (U-Tmod); TMOD3_MOUSE;

Rabbit

KLH conjugated synthetic peptide derived from human Tropomodulin 3: 21-120/352

IgG

Liquid

affinity purified by Protein A

Polyclonal

40 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of Actin filaments. A component of the membrane skeleton, tropomodulin binds to the amino-terminus of Tropomyosin, which coats the surface of Actin, and thus blocks the elongation and depolymerization of Actin filaments. Four tropomodulin isoforms, tropomodulin 1-4, have been characterized in humans. Tropomodulin expression is isoform-specific; tropomodulin 3 is expressed ubiquitously, whereas tropomodulin 2 and tropomodulin 4 are expressed in neuronal tissue and muscle, respectively. Ubiquitous expression of seven tropomodulin 3 transcripts, ranging in size between 1 and 9.5 kb, have been identified by Northern Blot analysis on human tissues. The human TMOD3 gene maps to chromosome 15q21.2, within the same region as the gene for amyotrophic lateral sclerosis 5 (ALS5), and encodes a 352 amino acid protein. Tmod3, the mouse homolog to human TMOD3, is present as early as day 7 in embryonic development and is expressed throughout development.