HMGCR重组兔单抗

bsm-52822R

重组兔单抗

HMGCR Recombinant Rabbit mAb

HMGCR重组兔单抗

LDLCQ3; LGMDR28; MYPLG; HMG-CoAR; Red; 3H3M; HMDH_HUMAN; HMGCR; HMG-CoA reductase; 1.1.1.34; HMDH_MOUSE; HMDH_RAT;

Rabbit

A synthesized peptide derived from human HMGCR: 400-500

IgG

Liquid

affinity purified by Protein A

Recombinant

7C5

97 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].