细胞信号转导分子Smad-1重组兔单抗

bsm-52222R

重组兔单抗

Smad1 Recombinant Rabbit mAb

细胞信号转导分子Smad-1重组兔单抗

BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1; Mad1; Mlp1; MusMLP; dwf-A; mMad1; SMAD1_HUMAN; SMAD1; MAD homolog 1; Mothers against DPP homolog 1; Mad-related protein 1; SMAD family member 1 (SMAD 1 | Smad1 | hSMAD1); Transforming growth factor-beta-signaling protein 1 (BSP-1); SMAD1_MOUSE; Dwarfin-A (Dwf-A); Mothers-against-DPP-related 1 (Mad-related protein 1 | mMad1); SMAD family member 1 (SMAD 1 | Smad1); SMAD1_RAT;

Rabbit

A synthesized peptide derived from human SMAD1: 220-280

IgG

Liquid

affinity purified by Protein A

Recombinant

2D9

52 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Smads最新发现的TGF-β信号转导途径中一个重要的新基因家族.是TGF-β特异的细胞内信号转导分子，SMAD1属于受体激活的SMADs.有学者认为：Smad1在某些肿瘤中发生突变,有可能是一种肿瘤抑制基因。

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].