沉默调节相关蛋白2重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
沉默调节相关蛋白2重组兔单抗
货号:bsm-52221R
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概述

产品编号
bsm-52221R
产品类型
重组兔单抗
英文名称
SIRT2 Recombinant Rabbit mAb
中文名称
沉默调节相关蛋白2重组兔单抗
英文别名
SIR2; SIR2L; SIR2L2; SIR2_HUMAN; SIRT2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; SIR2-like protein 2; 2.3.1.286;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SIRT2: 1-28
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4G12
理论分子量
36 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
沉默调节相关蛋白2重组兔单抗沉默调节相关蛋白2重组兔单抗沉默调节相关蛋白2重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
IHC-PHumanMouse, Rat1:100-500
IHC-FHumanMouse, Rat1:100-500
IFHumanMouse, Rat1:100-500

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
SIRT2
蛋白名
NAD-dependent protein deacetylase sirtuin-2
亚细胞定位
Cytoplasm, cytoskeleton. Colocalizes with microtubules.
组织特异性
Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
翻译后修饰
Phosphorylated at the G2/M transition of the cell cycle.
相似性
Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
功能
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.

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