This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:500-2000
IHC-P
Human
Mouse, Rat
1:100-500
IHC-F
Human
Mouse, Rat
1:100-500
IF
Human
Mouse, Rat
1:100-500
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
SIRT2
蛋白名
NAD-dependent protein deacetylase sirtuin-2
亚细胞定位
Cytoplasm, cytoskeleton. Colocalizes with microtubules.
组织特异性
Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
翻译后修饰
Phosphorylated at the G2/M transition of the cell cycle.
相似性
Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain.
功能
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.