SIRT2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bsm-52221R

重组兔单抗

SIRT2 Recombinant Rabbit mAb

沉默调节相关蛋白2重组兔单抗

SIR2; SIR2L; SIR2L2; SIR2_HUMAN; SIRT2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; SIR2-like protein 2; 2.3.1.286; sirtuin 2; sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)

Rabbit

A synthesized peptide derived from human SIRT2: 1-28

IgG

Liquid

affinity purified by Protein A

Recombinant

4G12

36 kDa

36-45 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

SIRT2

NAD-dependent protein deacetylase sirtuin-2

Cytoplasm, cytoskeleton. Colocalizes with microtubules.

Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.

Phosphorylated at the G2/M transition of the cell cycle.

Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.

NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.