Lipoprotein lipase Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss
货号：bs-1973R
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概述
产品编号
bs-1973R
产品类型
农牧业/家禽抗体
英文名称
Lipoprotein lipase Rabbit pAb
中文名称
脂蛋白脂酶抗体
英文别名
HDLCQ11; LIPD; LIPL_BOVIN; LPL; Phospholipase A1; 3.1.1.34; LIPL_HUMAN; LIPL_MOUSE; lipoprotein lipase
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human LPL: 401-475/475
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
52 kDa
检测分子量
60 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Lipases
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
Metabolism > Types of disease > Cancer
Metabolism > Types of disease > Obesity
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
脂蛋白脂酶（lipoprteinlipase，LPL）是甘油三酯降解为甘油和游离脂肪酸 (FFA)反应的限速酶,是脂肪细胞、心肌细胞、骨骼肌细胞、乳腺细胞以及巨噬细胞等实质细胞合成和分泌的一种糖蛋白与机体的脂质代谢及肥胖与否密切相关. 近年来研究认为：LPL可通过粘附作用，促进了单核细胞血管内皮细胞及肿瘤坏死因子（TNF）的分泌、血管平滑肌细胞增殖等因素，导致动脉粥样硬化的加重。
背景资料
Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, GuineaPig | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, GuineaPig | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, GuineaPig | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, GuineaPig | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Sheep, Cow, GuineaPig | 0.2μg /test |
交叉反应
交叉反应: Human, Rat (predicted: Mouse, Rabbit, Pig, Sheep, Cow, GuineaPig)
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靶标
基因名
LPL
蛋白名
Lipoprotein lipase
亚基
Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1.
亚细胞定位
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
组织特异性
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T lymphocytes, neutrophils, monocytes, B lymphocytes, and myeloid cells.
翻译后修饰
Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
疾病
Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.
相似性
Belongs to the AB hydrolase superfamily. Lipase family.
Contains 1 PLAT domain.
Contains 1 PLAT domain.
功能
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
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