Cyclophilin B Recombinant Rabbit mAb, Loading Control (一抗) - WB | Bioss

Rrmab?兔单抗
Cyclophilin B Recombinant Rabbit mAb, Loading Control (一抗) - WB | Bioss
货号:bsm-52473R
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概述

产品编号
bsm-52473R
产品类型
内参抗体、重组兔单抗、胞质(包浆或全细胞)内参抗体
英文名称
Cyclophilin B Recombinant Rabbit mAb, Loading Control
中文名称
亲环蛋白(亲环素)PPIB(内参)重组兔单抗
英文别名
CYP-S1; CYPB; HEL-S-39; OI9; SCYLP; Cphn-2; Cphn2; CyP-20b; PPIB_HUMAN; PPIB; PPIase B; Cyclophilin B; Rotamase B; S-cyclophilin (SCYLP); 5.2.1.8; PPIB_MOUSE; PPIB_RAT; peptidylprolyl isomerase B; peptidyl-prolyl cis-trans isomerase B; S-cyclophilin
抗体来源
Rabbit
免疫原
Recombinant human Cyclophilin B: C terminus
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4A10
理论分子量
20 kDa
检测分子量
20 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
The cyclophilins are a conserved class of proteins that bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. CsA blocks helper T-cell activation at a step between T-cell receptor stimulation and the transcriptional activation of cytokine genes. Cyclophilins from many species possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that is blocked by CsA and therefore may be relevant in CsA-mediated immunosuppression.
亲环蛋白(亲环素)PPIB(内参)重组兔单抗-bsm-52473R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
PPIB
蛋白名
Peptidyl-prolyl cis-trans isomerase B
亚细胞定位
Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
疾病
Defects in PPIB are the cause of osteogenesis imperfect ype 9 (OI9) [MIM:259440]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.
相似性
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Contains 1 PPIase cyclophilin-type domain.
功能
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

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