Ceruloplasmin Rabbit pAb (一抗) | Bioss

bs-2373R

宠物抗体

Ceruloplasmin Rabbit pAb

铜蓝蛋白抗体

AB073614; CP-2; D3Ertd555e; CERU_HUMAN; CP; Cuproxidase ceruloplasmin; Ferroxidase ceruloplasmin; Glutathione peroxidase ceruloplasmin; Glutathione-dependent peroxiredoxin ceruloplasmin; CERU_MOUSE;

Rabbit

KLH conjugated synthetic peptide derived from human Ceruloplasmin: 551-650/1065

IgG

Liquid

affinity purified by Protein A

Polyclonal

120 kDa

140 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    铜蓝蛋白（ceruloplasmin,CER）又称铜氧化酶，是一种含铜的α2糖蛋白，CER具有氧化酶的活性，起着抗氧化剂的作用。在血循环中CER的抗氧化活力可以防止组织中脂质过氧化物和自由基的生成，特别在炎症时具有重要意义,也属于一种急性时相反应蛋白。
    铜蓝蛋白对多酚及多胺类底物有催化其氧化之能力铜蓝蛋白具有遗传上的基因多形性。其作用为调节铜在机体各个部位的分布、合成含铜的酶蛋白.一般认为铜蓝蛋白由肝脏合成，一部分由胆道排泄，尿中含量甚微。铜蓝蛋白测定对某些肝、胆、肾等疾病的诊断有一定意义。

Caeruloplasmin is a copper binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132kDa and occurs in plasma at a concentration of 150-500 mg/L. Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95% of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant and an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation and trauma and it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson’s disease, where levels are greatly reduced. Caeruloplasmin is extremely labile in plasma and rapidly degrades to 115kDa and 19kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of caeruloplasmin.