phospho-GRK2 (Ser29) Rabbit pAb (一抗) - IHC-P,IHC-F,IF | Bioss

bs-16683R

磷酸化抗体、宠物抗体、农牧业/家禽抗体

phospho-GRK2 (Ser29) Rabbit pAb

磷酸化G蛋白偶合受体激酶2抗体

ADRBK1; BARK1; BETA-ARK1; GRK-2; ARBK1_HUMAN; GRK2; Beta-ARK-1; G-protein coupled receptor kinase 2; 2.7.11.15; BARK; ARBK1_MOUSE; G-protein-coupled receptor kinase 2; ARBK1_RAT; G protein-coupled receptor kinase 2; adrenergic, beta, receptor kinase 1; beta-adrenergic receptor kinase 1; GRK2 (phospho-S29); p-GRK2; phospho-GRK2; GRK2 (phospho-Ser29)

Rabbit

KLH conjugated synthesised phosphopeptide derived from human GRK2 around the phosphorylation site of Ser29: RA(p-S)KK

IgG

Liquid

affinity purified by Protein A

Polyclonal

76 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

G蛋白偶联受体激酶2(GRK2)是催化激动剂诱导的GPCR磷酸化以及启动GPCR脱敏的关键激酶,主要用于GRK细胞膜转位和对GRK功能的影响.

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].